Robimy badania osobom z zespołem Downa na obecność cholesterolu w rozbiciu. Jak zwykle wydaje się, że całościowo nie jest źle, ale po głębszej analizie mamy problem w proporcji LDL (“zły cholesterol”) do HDL. LDL jest stosunkowo za wysoki. Patrzymy na trójglicerydy i są one dużo za duże. Powstaje pytanie i co dalej?

Najlepszą metodą jest wspomaganie organizmu suplementami zawierającymi wielonienasycone kwasy tłuszczowe z grupy Omega 3, a w szczególności DHA. W wielu badaniach (poniżej jedno z nich) stwierdza się, ze DHA ma istotny wpływ na poziom koncentracji HDL, LDL i trójglicerydów. Podawanie przez minimum 45 dni powoduje poważne zmniejszenie poziomu koncentracji trójglicerydów oraz wpływa na LDL poprzez ograniczenie jego dystrybucji w organizmie.

Jak stosować suplementację Omegami przeczytacie tutaj:

http://www.stowarzyszenie-razem.org/zdrowie/suplementy-dieta/suplementy-podawanie.html

więcej o Omegach tutaj:

http://www.stowarzyszenie-razem.org/zdrowie/suplementy-dieta/omega-co-to-jest.html

http://www.stowarzyszenie-razem.org/files/Omega3ijegoznaczeniewobnianiuryzykachorb_EE9A/omega2.pdf

2007-08-01

AJCN – DHA Improves Lipid Profiles

Kelley DS, Siegel D, Vemuri M, et al. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. Am J Clin Nutr. 2007;86(2):324-33

BACKGROUND: The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.

OBJECTIVE: We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.

DESIGN: Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.

RESULTS: DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.

CONCLUSION: DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.

Source: PMID: 17684201

2009-02-05

ATVB – Omega-3 Rich Diets Decrease Arterial Total LDL Delivery

Chang CL, Seo T, Matsuzaki M, et al. n-3 Fatty Acids Reduce Arterial LDL-Cholesterol Delivery and Arterial Lipoprotein Lipase Levels and Lipase Distribution. Arterioscler Thromb Vasc Biol. 2009 Feb 5

OBJECTIVE: We previously reported that saturated fat (SAT)-enriched diets increase arterial cholesteryl ester (CE) deposition, especially from LDL-selective uptake (SU), and this was associated with increased arterial lipoprotein lipase (LpL). We now question how n-3 fatty acid rich diets influence arterial cholesterol delivery and arterial LpL levels.

METHODS AND RESULTS: C57BL/6 mice were fed chow or eucaloric high-fat diets enriched in SAT or fish oil (n-3) for 12 weeks, and then injected with double radiolabeled or fluorescent-labeled human LDL to separately trace LDL-CE and LDL-apoB uptake. SAT and n-3 diets increased plasma cholesterol levels similarly; n-3 diets lowered plasma triglyceride concentrations. SAT increased arterial LDL-SU with significantly higher CE infiltration into aortic media. In contrast, n-3 markedly reduced total LDL uptake and CE deposition and abolished SU with LDL localized only in aortic intima. Disparate patterns of CE deposition between diets were consistent with distribution of arterial LpL-SAT diets induced higher LpL levels throughout the aorta; n-3 diets decreased LpL levels and limited LpL expression to the aortic intima.

CONCLUSIONS: n-3 rich diets decrease arterial total LDL delivery and abrogate LDL-SU in parallel with changing arterial wall LpL expression and distribution.

Source: PMID: 19201689

Zobacz również:

• 2009.03.22 – podawanie suplementów, aktualizacja
• 2009.05.14 – składamy zamówienia na suplementy
• PROJEKT: WSPOMAGANIE EDUKACJI
• 2009.01.12 - Syntetyczny HDL, czyli jak można skutecznie walczyć z cholesterolem
• 2009.02.01 – Suplementacja dzieci z zespołem Downa na nie…a może jednak na tak
• 2009.03.23 – dzisiaj macie dwa artykuły do przeczytania…
• Small Steps, czyli Małe Kroki
• PROJEKT: MEDYCZNY
• 2009.01.22 - Omegi zaczynamy kształcenie
• 2009.02.03 – Dyskusja o suplementach trwa…

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